Up-and-coming
New.The woman is an up-and-coming singer.
Up and away
Up into the air and into flight.My parents got on the airplane and were quickly up and away.
Up and at ’em
Active and busy, up and at them.We will be up and at 'em very early tomorrow morning.
Up and around
Out of bed and moving around, moving from one place to another.I was up and around before 6:00 AM this morning.
Up and about
Healthy and moving around, not sick in bed.My uncle has been up and about for a couple of days since he left the hospital.
Up against (something)
Close to something.The ladder was standing up against the tree in the yard.
Up against (someone or something)
Having trouble with someone or something.The student came up against many problems when he went to university.
Up a blind alley
On a route that leads nowhere, at a dead end.The police were up a blind alley in their search for evidence of the crime.
Until the cows come home
Until very late.It is my birthday today and I plan to party until the cows come home tonight.
Toss off (something) toss (something) off
To throw something off of oneself or something.I tossed off my jacket before I got into the car.