Use every trick in the book
To use every method possible.The apartment manager used every trick in the book to force the young family to leave.
Uptight
To be worried or irritated or anxious.My sister is very uptight because of her exams.
Upside down
With the upper side turned toward the lower side.The boat was upside down in the water.
Upshot of (something)
The result or outcome of something.The upshot of the meeting was that we would no longer continue to keep the store open.
Upset the applecart
To ruin or spoil a plan or idea."Try not to upset the applecart as we have spent a lot of time working on this project."
Ups and downs
Good fortune and bad fortune, good times and bad times, difficulties.My cousin is having a few ups and downs but generally he is doing well.
Upper hand
A controlling power, an advantage.The union members have the upper hand in their negotiations with the company.
Upper crust
Rich and famous people, the highest class of people.The private club was full of the upper crust of the city.
Upon one’s head
To be one's own responsibility.The responsibility for the event was put upon my head.
Up until
Until.I was in the library up until midnight last night.